Matt:
I was fishing outside Dana Pt. on Monday and there was some heavy areas of red tide off Doheny. So the best bet right now is south of the harbor towards Capo beach and San Clemente Pier and the other areas north of the harbor. I went south on Monday and other then having a T-shark bite and then break-off, I had a no-fish day, the first time for me fishing off my kayak
Vikingj (Wayne) stated you can launch out of Doheny, but I think they have just recently stopped kayaker's from launching off the beach north of the San Juan Creek river mouth due to conflict with surfers.
There are some very big fish just outside the harbor; last Sunday, a kayaker pulled in a 56 pound white seabass.
Good luck to you. I am planning to fish Newport Harbor on Wednesday.
Kevin