Definitely go when you can, especially La Jolla, where you can have a killer bite anytime. But I'll go a little deeper into your question, at the risk of pissing a lot of people off due to giving out secrets
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If your after a particular species, you may want to consider it's needs, it's particular bite... For example, Pelagic species come and go, and you do not want to be fishing for them, well when they are not there. Threshers come to mind. They have a pup season, and the pups tend to swim up the coast, in much shallower waters that the large adults. Knowing this timing, in the local area can be critical. White sea bass is another. Although they can be caught anytime they are around, the bite is phenomenally better during their breeding season. But then, for the bite to really turn on, water temp is critical.
Id suggest you attend the up-coming Fred Hall show, check out some of the seminars, and perhaps purchase yourself a few well written species specific books. Otherwise, or in addition to, book a trip or 2, or 3 with some of the kayak guides.